Yutopar Beta Agonists, Post Partum Hemorrhage, Beta 2 Agonists, Insulin Requirements, Muscle Relaxation
Ritodrine hydrochloride (trade name Yutopar) is a tocolytic drug, used to stop premature labor. It is available in oral tablets or as an injection. ... more »
Ritodrine hydrochloride (trade name Yutopar) is a tocolytic drug, used to stop premature labor. It is available in oral tablets or as an injection.
Ritodrine is a Beta-2 adrenergic receptor agonist - a class of medication used for smooth muscle relaxation (other types are used in asthma or other pulmonary diseases like salbutamol)
Side effects and potential contraindications
Most side effects of beta-2 agonists result from their concurrent beta-1 activity, and include increase in heart rate, rise in systolic pressure, decrease in diastolic pressure, chest pain secondary to MI, and arrhythmia. Beta agonists may also cause fluid retention secondary to decrease in water clearance, which when added to the tachycardia and increased myocardial work, may result in cardiac failure. In addition, they increase gluconeogenesis in the liver and muscle resulting in hyperglycemia, which increases insulin requirements in diabetic patients. The passage of beta-agonists through the placenta does occur and may be responsible for fetal tachycardia, as well as hypoglycemia or hyperglycemia at birth.
Patients with Type 2 Diabetes, high blood pressure or migraines should bring this to their doctor's attention before receiving care.
It has also been associated with post-partum hemorrhage.