Singulair Connective Tissue Disorders, Systemic Corticosteroid Therapy, Strauss Syndrome, Churg Strauss, Liver Injury
STRANGELY ENOUGH THE CORRECT INFORMATION IS SHOWING UP IF YOU HIT REPLY SO DO THAT!
Zsmom - IN ADDITION READ THE POST MARKETING EXPERIENCE ON THE BOTTOM OF PAGE 15 OF THE PRESCRIBING INFO FOR SINGULAIR ON THEIR WEBSITE (http://www.merck.com/product/usa/pi_circulars/s/singulair/singulair_pi.pdf) IT READS: The following additional adverse reactions have been reported in post-marketing use: Blood and lymphatic system disorders: increased bleeding tendency Immune system disorders: hypersensitivity reactions including anaphylaxis, very rarely hepatic eosinophilic infiltration Psychiatric disorders: agitation including aggressive behavior, anxiousness, dream abnormalities and hallucinations, depression, insomnia, irritability, restlessness, suicidal thinking and behavior (including suicide), tremor Nervous system disorders: drowsiness, paraesthesia/hypoesthesia, very rarely seizures Cardiac disorders: palpitations Respiratory, thoracic and mediastinal disorders: epistaxis Gastrointestinal disorders: diarrhea, dyspepsia, nausea, very rarely pancreatitis, vomiting Hepatobiliary disorders: Rare cases of cholestatic hepatitis, hepatocellular liver-injury, and mixedpattern liver injury have been reported in patients treated with SINGULAIR. Most of these occurred in combination with other confounding factors, such as use of other medications, or when SINGULAIR was administered to patients who had underlying potential for liver disease such as alcohol use or other forms of hepatitis. Skin and subcutaneous tissue disorders: angioedema, bruising, erythema nodosum, pruritus, urticaria Musculoskeletal and connective tissue disorders: arthralgia, myalgia including muscle cramps General disorders and administration site conditions: edema In rare cases, patients with asthma on therapy with SINGULAIR may present with systemic eosinophilia, sometimes presenting with clinical features of vasculitis consistent with Churg-Strauss syndrome, a condition which is often treated with systemic corticosteroid therapy. These events usually, but not always, have been associated with the reduction of oral corticosteroid therapy. Physicians should be alert to eosinophilia, vasculitic rash, worsening pulmonary symptoms, cardiac complications, and/or neuropathy presenting in their patients. A causal association between SINGULAIR and these underlying conditions has not been established (see PRECAUTIONS, Eosinophilic Conditions).
Zsmom - this is the address for the patient info on singulair http://www.merck.com/product/usa/pi_circulars/s/singulair/singulair_ppi.pdf