Lipitor Drug Efficacy, Area Under the Curve, Cvd Risk, Classes of Drugs, Antidiabetic Agent

discovered mutation in a gene, SLCO1B1, which codes for a transport protein that is responsible for moving statins into the liver to be detoxified. Without this protein, statins build up in the blood stream lipreading to toxic levels. thus Statin poisoning can result. Studies have shown levels of statins at 400% HIGHER than normal. Imagine having that level of statins every day one takes the drug. this mutation IS NOT RARE. predicted to occur in 22% to 36% of Caucasian pop, less in african am and more in asian.
thus 20 to 36 persons out of 100 have this mutation. and if taking a statin have great likelyhood of suffering from greatly increased plasma statin levels. one couldgoogle "SLCO1B1+statin"
obtained genetic profiling from 23andme; there are many other cos out there offering the genetic testing, though one should check to make certain this mutation is tested for.
Many individuals with this mutation develop severe myalgias adnd myopathies prompting them to stop the drug. for those who do not get the muscle involvement, I think neurodegeneration can occur after therapy with this class of drugs that cannot be transported for detoxification correctly.
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