L-methylfolate is the natural, active form of folate used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. The un-methylated form, folic acid (vitamin B9), is found in leafy green vegetables. Synthetic folic acid works to replicate the action of folate, but must be broken down in a series of metabolic steps in order to become L-methylfolate. Approximately 10% of the general population (homozygous TT) lack the enzymes needed to receive any benefit from folic acid. Another 40% of the population (heterozygous CT) appear to convert only a limited amount of folic acid into L-methylfolate. They cannot fully process supplemental folic acid at RDA or higher dose levels. The remaining population do not have an MTHFR polymorphism and can fully metabolize folic acid.

Source: http://en.wikipedia.org/wiki/Deplin

Deplin Discussions

  1. link Chocolate12
    Hives. Nausea, Sleepy
    Within a minut of taking first pill I got hives on both of my arms and went from having energy to wanting to sleep all day and having nausea so bad th - 19% more...
    Chocolate12- over a year ago - 1 Reply - in Deplin
  2. link Rueterl
    Deplin Keeps me awake at night
    Doctor recommended taking before bedtime every night. Soon I was experiencing difficulty sleeping. Started taking a Rx sleeping pill and it helped som - 74% more...
    Rueterl- over a year ago - in Deplin
  3. link Db2010
    Deplin frige, extra energy, headaches, alot
    Since taking Deplin, I have experienced headaches everyday some worse than others, I just want to eat all the time, I have gained weight, I feel more - 56% more...
    Db2010- over a year ago - in Deplin
  4. link Brerohodo
    does deplin make you sleepy al day?
    does deplin make you sleepy in the day?
    Brerohodo- over a year ago - in Deplin
  5. link Waya333
    Deplin increased appetite, suicidal depression, meds, medication, little bit
    I am so glad that someone here posted about the increased appetite! I have been going crazy trying to figure out why after I take my night meds (and I - 83% more...
    Waya333- over a year ago - 1 Reply - in Deplin
  6. link Waya333
    Deplin insatiable appetite, hot flashes, trouble sleeping, wt, supplements
    Well something has been making me having an insatiable appetite but like some1 said here, the website said no wt gain. Other things I have noticed sin - 73% more...
    Waya333- over a year ago - in Deplin
  7. link Kimcra
    Deplin and contipation
    I have been on Deplin for a month now and I seem to be having a problem with constipation. Has anybody else had this problem? KJ
    Kimcra- over a year ago - in Deplin
  8. link Mjsudol
    What is the best time to take Deplin?
    When is the best time to take Deplin?
    Mjsudol- over a year ago - in Deplin
  9. link Leighznich
    Deplin feeling nauseous
    Been feeling nauseous since taking it, approx 10 days now. Energy has greatly improved though!
    Leighznich- over a year ago - in Deplin
  10. link Putzangel
    Side Effects if Deplin and interactions for Procarida and Nexium
    What are the side effects of Deplin? And I was prescribed it even though I do not take any anti-depressants. I am also concerned the interactions with - 13% more...
    Putzangel- over a year ago - in Deplin
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