Doxycycline Hyclate and prednisone

The drug insert for Doxycycline says to take the medicine with a full glass of water, and it warns not to lie down for a half hour after taking the drug. IT IS VERY IMPORTANT TO FOLLOW THE INSTRUCTIONS. Doxycycline, along with a number of other drugs, is quite corrosive.

I was on doxy for about a week when I woke up with the feeling of something caught in my throat. I had taken it with a full glass of water, but I had laid down immediately. I guess the pill had found its way back up to my throat. That night, I went to the hospital, did a barium swallow, and I eventually had an endoscopy to check out the damage. Thankfully it subsided after a couple weeks, but I had horrible pill-induced Esophagitis. I couldn't even drink water without pain and a feeling that I was choking. I didn't eat solids for 2 weeks, took double-dose Nexium, and I had to sleep SITTING UP because I also have silent acid-reflux, but when this happened, I could feel it intensely. I was lucky it wasn't perforated.

Anyway, lesson learned. Always follow the instructions. This can also happen with NSAIDs like Advil, btw.