Advair HFA and singulair

I am a physician and a patient. I have been on singulair and advair for several years now and had weight gain, anxiety, depression, and mild improvement in asthma that I could tell. I had pneumonia 4 times last year and thought it was the environment. I left the Midwest and moved to the east coast where I stopped my meds for several months and all the above symptoms resolved. I recently restarted them several weeks ago do to increase in symptoms and anxiety/panic attacks came back with a vengeance I stopped them and switched to other meds and wow the side effects are improving again. I am not going to take them or prescribe them again.

I recently went into an asthma attack that admitted me into the hospital on Sept 3rd. I was given albuterol treatments which I also use at home and have for 3 + years via nebulizer when needed. They also prescribed ADVAIR on Sept 4th or 5th and released me from the hospital. Once home my breathing started to decline despite using my nebulizer on time. By Monday night my breathing was shallow and my Cramps had severe pain onset. I began walking stiffly. I went to bed that night and my breathing continued to decline. In the morning I could hardly walk because of the pain in my calves. I could however sit and they "seemed " fine but turned in a bit. I took my children to school and at 8am dropped them off to the teacher at the curb check in. (Meaning I did not have to get out) I pulled aside to get out and see a friend and as I stepped out of the car my calves seized again. At the advice of my friend I decided to right away drive around the corner to the Medical Center where I go. I had an appt later that morning for follow up from Hospital, but decided I better not wait.
BY 8:10 I was in a red zone with my asthma Chest in FULL SEIZE (225 peak flow from over 375 an hour earlier using the peak flow meter I had in my car)
I got out of the car to go into the medical center and IMMEDIATELY Dropped DOWN a Foot and my Feet FLIPPED over my Knees Bowed out and I was walking like a Monkey. I scrambled to get into the medical center where I yelled for assistance and was given breathing treatment with no relief and sent to the Hospital via Ambulance. Breathing 3 breathing treatments in 3 hours no relief of Seizing in Chest. Xrays Clear. .I stayed there until Sept 16th where I have now been released, I am still walking monkey like , I have numbness in my face, a severe headache and I have not slept since Sept 14th at 5 am . I am not tossing and turning, I am wide awake.Today is Thursday Sept 18th. It took at least 3 days of before I was taken off ADVAIR. I had been on ADVAIR for at least 7-8 days 150/50 twice a day. I noticed a difference in my Chest muscle within 12 hours. My legs started to soften and not be so stiff within 1 or 2 days, however my feet drag sideways as I take a step. I have to swing my legs forward for each step. I directly link this to the ADVAIR.

My daughter was on Advair, Singulair, and Zyrtec to control her severe asthma and allergies. We were so thankful that these medications kept her from having to be hospitalized 2-3 times a year for uncontrollable asthma attacks. About six months after she began taking these medications she began to have headaches, she had difficulty sleeping, she was irritable, she had stomach pains, leg cramps,and eventually depression and social withdrawal. She went from an outgoing and happy teenager to a bitter and angry person. In 2003 she committed suicide. Six months after her death reports started to surface about the link between singulair and depression and suicide. Perhaps for my daughter it was a combination of the three drugs. Whatever you do be cautious and do your research before taking any allergy or asthma medication. Go to the Singulair website and you will be astounded by what you read. Please try to get the word out about these medications.

I was diagnosed with adult allergic asthma one year ago at 38 years old. I started having problems breathing ONLY AT NIGHT on occasion and palpitations. Had a physical and ekg, totally normal. Went to allergist and they said I have alot of allergies and diagnosed me with the asthma. Funny thing, weeks before I niked 20 miles, hiked 12 miles, canoed 3 miles, played golf in a 3 day span and no problems. Since they told me this and started me on advair I haven't been able to jog more than 2 miles or bike more than 8 to 10.

Its very strange indeed, I have gotten more paranoid feelings when just get a little out of breath, and sometimes cant keep still in a car or sitting down.

I cut back on sugar, sodium and started exercising a little every day, only 15 minutes. But came down with a cold recently and back to square one. I am trying to take the advair only ONCE a day instead of twice and almost feel withdrawal symptoms like shakiness, paranoia, irritability. Does anyone have any idea about this? I am really confused! Thanks... J

I hope this helps someone.

I was never allergic to anything in my life until I went around this cat at the age of 33. I sneezed and got a really scratchy throat. I thought it would go away, but it turned into a cold. I thought the cold would go away, but it turned into bronchitis and then pneumonia. I was jogging everyday at the time and realized something was wrong when I couldn't finish my run.

I was hospitalized for two days and upon discharge I was stocked up with a cocktail of drugs: Singular, Advair, Albuterol inhaler, and Claritin. Needless to say, I took them all, because I was scared of dying. Thank God I'm not a good medicine taker, because I missed many doses and only took them as needed. I think this is why after 3 years I have only started to see the effects of these meds in the last 8 months.

Okay... I have major joint stiffness(all over) especially neck and fingers, heart palpitations, nervousness, short patience, horrible memory, lack of motivation. Oh my God! The weight gain...Please!

Before this, I was completely healthy. After reading this I will reduce myself to my inhaler and Claritin. I notice they are cool. Otherwise, if I keep my stress level down my breathing does really well. It would probably help if I got rid of the cat. Shhhh...Don't tell anyone. LOL.

I have since put my self on a juice fast using a high powered juicer to cleanse my system of all the trash the doctors gave me.

God bless you all and I speak life and breath into each of our lives.

BreatheWrite.

I'm 18 years old and I've been taking Advair (500) for about 4 years. I've had very persistant asthma my whole life and my Advair seems to save me from having to use my albuterol around 6 times a day. About 9 months ago i lost my voice for over 2 months. After that went away I had a break for about one month then around 6 months ago I developed what seems like a smokers cough yet I don't smoke. I just got a chest x-ray done and they said it was normal. They put me on steroids and antibiotics but it doesn't seem to be helping.

Could it be the Advair? I don't know that I can go without it even if it is. I want to get rid of this congestion in my lungs. I'm sick of coughing up mucus daily. Does anyone have any advice?

I was prescribed advair for mild asthma. I only took it for a few months before hearing somewhere that it could actually make asthma worsen, I never checked to make sure it was a fact but I actually felt it did make my asthma worse. Needless to say, I got off of it right away and switched to singulair for it, I find that much better.

I've been on Advair for probably 5 years. It has kept my asthma under control very well. Right now I take 250/50 and I'm down to one puff a day. I notice some of the side effects mentioned here, especially leg cramps. My weight has always fluctuated, so I can't blame that on Advair, in fact, I lost 60 pounds a couple of years ago while on Advair. I do have hoarseness that I'm sure is attributed to Advair. I take allergy shots and I'm almost to a maintenance level now. I'm hoping that between the shots, acupuncture, and a low dose of Advair, I will maintain my asthma control without the side effects. By the way, I also take Singulair which I think helps.

I tried to cut down on my Advair usage because it's so darned expensive - close to $200 a month. I only did one puff in the morning. I continued taking my Singulair as prescribed, once a day, at night. I had to go back to using Advair twice a day when I found I couldn't walk up two flights of stairs without difficulty breathing. But the thing that I hate the most is the coughing and the yellow mucus. Does anyone have this problem? I breathe better after expelling the mucus but sometimes it's so hard to do, I have actually coughed up blood. I have, also, lost my regular voice. At times I sound completely hoarse, and forget about singing, That's gone. I ask the pharmaceutical companies, if I must continue taking these drugs, can you make a version I can afford!

Hi all. Thank you for the posts-- this helps put my own symptoms in perspective. I'm a 28-yr old female and have had severe asthma since I was a toddler--which resulted in a childhood full of long hospital stays and all kinds of toxic drugs which aren't even prescribed anymore. I've been taking advair for about 3 months and have noticed that my mood has been off. I'm normally a peaceful person, not easily rocked, practicioner of yoga, etc. But for the last 3 months I've had sleeping problems (very severe in the 1st month-- to the point that I couldn't sleep at all) and have been experiencing anxiety, with heightened awareness of my breathing patterns and the occasional racing heartbeat. I've *never* had anxiety before. I went in for an EKG and they found that my heart is normal. Since I'm not a worrier or a person who is prone to anxiety, this was very disturbing for me-- I couldn't understand what the underlying cause was. This has had negative effects on my work life and my personal relationships--I'm just not as energetic as I used to be. I'm going to go off the drug and will report back to this website if I notice an improvement in my anxiety levels and sleep patterns. If so, then the cause will be obvious.

I wanted to make one more post just to raise awareness about another asthma drug I've tried. I took singulair in the past (about 5-6 years ago). At first it was a wonder drug-- totally clearing up all symptoms allergy and asthma related. But it did a number on my digestive track for the first 3-6 months of use-- I could not digest anything (and I eat very healthily--lots of fresh fruits and veggies everyday and little meat). I eventually went off that drug and tried it again this past year after a bad bout of the flu and some consequent sinus infections. I only took it 3 times and each night I had a horribly violent nightmare. Normally, I'm what you might call a happy dreamer-- maybe an average of 1 nightmare per year, if even. I stopped taking singulair on the 3rd night, and on the 4th night my dreams went back to normal. This was truly a disturbing experience, and I feel sure that singulair was responsible-- all the dreams were of a paranoid nature. I haven't had a dream like that since, and it's been more than a year since I stopped taking that. Asthma medication seems to have the potential for psychological side effects that everyone should be aware of. It is only fair that doctors warn their patients so that they know what any possible changes in their moods might be from. I really wish my doctor would have mentioned something to me. I'm sure I would have tried both drugs anyway, since I also know that people react different to different medications. But I certainly wouldn't have stayed with Advair as long as I have, knowing what I know now.

I wish all of you health, peace and happiness. I hope you are able to get well and live normal lives.

I am very skeptical of all of the claims I have read here. I am no advocate of GSK or any other drug company for that matter, but I think people are getting carried away with attributing their symptoms to Advair. The known side-effects are readily available, anything else is purely based on assumption. I agree that Advair may in fact have many more possible adverse effects than they let the public know, but let us be careful about making ourselves little scientific researchers and concluding a causal relationship based upon a single case study (and an informal one at that). Talk to your doctor about trying something with less risk, such as Singulair, Azmacort, Intall, Fluticasone Propionate, etc. Please though, be careful not to be so quick to claim generalizable findings based on your specific case. I myself am going to work with my physician to attempt a gluten-free diet and a less invasive medication therapy. Advair is not habit-forming or addictive, so withdrawals are doubtful at best. Read up on the pharmacology of Advair (salmeterol in particular), and you can come to your own conclusions. Best wishes to all of you fellow asthmatics!

I am very grateful for this blog because your collective experiences helped me figure out why I've been having depression and anxiety. I started on Advair 100/50 about 2 years ago and experienced wonderful relief from asthma symptoms. The drug seemed like a godsend.

However, just recently my boss noticed that my personality had changed, and she asked me if everything was OK. I said I've had a lot of trouble with depression and anxiety lately. I was just attributing it to aging (I'm 54).

Now after reading the many entries here about depression and anxiety, I realize that my symptoms are probably caused by the Advair. I've actually had the symptoms for quite some, but they were subtle at first, so I didn't link them to the Advair.

I'm going back to my doctor to see if I can get off of this stuff. I'm currently down to one puff per day, but I experience serious asthma symptoms when I try to quit completely. I'll probably need to go back to using a nebulizer at least during the withdrawal period.

Hi All -

I hate to read how Advair has affected all of your lives negatively however, after reading the information on this site, I feel so much better about what I have been experiencing.

I have had asthma all of my life. I was taking Albuterol (as everyone does) to control it when I had an attack, Singulair and Serevent (only prior to exercising to help stop an attack from happening). I went to a new pulmonary doctor with a bought of severe bronchitis and he told me that I was "not controlling my asthma properly" and that I should have been on Advair a long time ago. I trusted him and started taking it twice a day.

I have been on it for 17 days and over the past five days I started having severe anxiety over my breathing functions. I was monitoring every breath I took and wasn't breathing unless I told myself to. This started causing severe panic attacks...I HAVE NEVER DONE THIS BEFORE IN MY LIFE!!!!! I am not prone to anxiety or anything like that and I have had asthma ALL MY LIFE!!! This was an entirely new behavior. I thought I was going crazy...I couldn't stop thinking about breathing.....I analyzed what was new in my life and what I have been doing differently that could cause this change in my life and the only new thing was Advair. My husband had to give me a Xanax (something that I have never taken in my life) just so that I could function and go to work. So I went on line and I found at least 50 web sites like this one devoted to Advair and a link to panic attacks, anxiety, depression, etc...I STOPPED TAKING IT!!!!! I don't care what my doctor has to say...the benefits are not worth this drug taking over my life and changing me as a person. I am done. I will deal with my asthma as I have always done so and I don't care if he thinks that I am "not controlling it". I left a message for the doctor and I am still waiting to hear back. I haven't taken the Advair since yesterday morning and the panic attacks have started to get milder. I am still a little bit focused on the breathing but only if I am alone and not preoccupied. I have to believe that these side effects will go away in time and when the drug is out of my system. I learned a valuable lesson. I will only take a drug if I research it first.

Thank you all for your comments....you have helped me to preserve my sanity. We all can't be feeling the same thing and not attribute it to the culprit..ADVAIR!!!!