Lithium Citrate Information

What's inside Lithium Citrate

Lithium Citrate in the News

This Month in Archives of General Psychiatry - Archives of General Psychiatry
Yildiz et al (SEE ARTICLE) tested the antimanic efficacy of the centrally active protein kinase C (PKC) inhibitor tamoxifen citrate in a randomized, ...
Mon Mar 03 16:05:43 -0500 2008

Lithium Citrate Chemical Information

lithium citrate - The citrate salt of lithium, a monovalent cation with antimanic activity. Lithium citrate interferes with transmembrane sodium exchange in nerve cells by affecting sodium, potassium-stimulated adenosine triphosphatase (Na+, K+-ATPase); altering the release of neurotransmitters; reducing cyclic adenosine monophosphate (cAMP) concentrations and modulating cAMP second-messenger processes; and suppressing signal transduction pathways through the depletion of intracellular inositol and inhibition of the enzyme, glycogen synthase-kinase-3 (GSK-3). The exact mechanism through which lithium citrate exerts its mood-stabilizing effect is not fully known.