Hydrochlorothiazide-Lisinopril Information

What's inside Hydrochlorothiazide-Lisinopril

Recent Hydrochlorothiazide-Lisinopril Side Effects

Posted by marvinnel 11 days ago
i started new lisinopril from lupin phar macy in india walmart brand and my blood pressure skyrocketed.. went back to my ...

Posted by mb2008 11 days ago
I have been taking 10mg of Lisinopril once a day for about a month, at 1st I was prepared to become dizzy due to the warning ...

Posted by donnao 15 days ago
Started taking lisinopril 4mos ago. Side-effects are extreme fatigue,weakness ,shortness of breath, temperature sensitivity-f...

Hydrochlorothiazide-Lisinopril Chemical Information

hydrochlorothiazide - The hydrogenated derivative of chlorothiazide, a thiazide diuretic with antihypertensive and anti-urolithic effects. This agent binds to the electroneutral Na-K-Cl cotransporter (NKCC) and thereby impairs Na+, K+ and Cl- reabsorption on the luminal membrane of the early segment in the distal convoluted tubule in the kidney. This leads to an increase in urinary excretion of sodium, chloride, potassium, bicarbonate and water subsequently reducing plasma and extracellular fluid volume leading to a reduction in blood pressure. Hydrochlorothiazide also decreases urinary calcium and uric acid excretion by direct action on the distal tubule.

lisinopril - A synthetic peptide derivate and long-acting angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Lisinopril specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II. This leads to a diminished vasopressor activity. In addition, angiotensin II-stimulated aldosterone secretion by adrenal cortex is decreased which results in a decrease of sodium and water retention and an increase of serum potassium.