I have been on doxy for 2 weeks for acne. I am 44 and get cysts under my skin. Not noticeable to anyone but me really. Finally yesterday I realized that every morning I wake up extremely fatigued and a 1/2 lb heavier. I am somewhat of an athlete and watch my diet and found this very strange. I have dark circles under my eyes and this incredible bloated look and feeling unlike anything I have every experienced, It has to be the doxy because that is the only new thing I have introduced in to my system. Ugh. I have to stop taking it. I'll deal with the zits.