Prescribed for UTI, 1 pill 2x day, actually Bactrim DS, which is 800/160 tabs. After 1 dose, next morning severe migraine with vomiting, nausea, chills, (I didn't take temp, but probably had a fever), loss of appetite, finally went to sleep for a few hours and was jarred awake by a bad dream (unusual for me) and couldn't go back to sleep thought I had drank to much caffeine. Had tight chest, but thought that was linked to my 130/90 BP...I thought I was having a heart attack. Followed by sleeplessness last night. Today, after 3 doses, I woke with a stiff neck and had a headache this morning which was made better by 2 Tylenol. Went to my GP to get on some BP meds. He must've thought I was crazy, but I wasn't leaving until I got something to make my chest feel better and theoretically lower my BP. I thought all these side effects were just me, but apparently not. I wish everyone the best in finding a better, safer treatment than this one.