I am a 61 yr. old female former smoker diagnosed with COPD/emphysema. I was put on ADVAIR 500, along with using a nebulizer with albuterol and bromide to "inhale" several times a day.I also was on oxygen. I quit smoking and worked at getting my health back and to the surprise of the doctors went back to playing tennis several times a week.After reading about the side effects of the high dose Advair I had my Dr. reduce the amount to 250. It has been almost a year now that I have been on Advair. I have noticed some of the side effects mentioned here. The leg cramps, and leg spasms have been horrid. I also have had blurry vision. And lately I seem to not be able to sleep even if I am tired.I am going to see if my Dr. will let me drop to the 100 Advair level. Lately I have been intentionally skipping Advair doses to see if I notice any difference in my breathing. I almost forgot- since going on the meds listed above I have had kidney stones, an emergency appendix surgery and now high bilirubin count. I cannot find any info on those problems if result of medication ADVAIR. Even though I smoked for a number of yrs. I was very active and not over weight. The Dr. thinks thats why I am back to playing tennis. Has anyone else had a gastro problems ??Thanks A.