Treatment of depression symptoms and conditions

The example that I am posting below is not the only patent for an aminoquinoline derivative that is proposed for the treatment of neuro-psychiatric disorders. Even though we are not comparing exact chemical structures, it is certainly worth considering how the quinolines relate to this receptor.

It is also worth considering why montelukast, a quinoline, seems to be causing some of the problems that this owners of this particular patent think that they can treat.

As I mentioned before, I have no answers. Regardless of how small Merck believes the population of Singulair patients who suffer neuro-psychiatric disorders is, I do not believe that any patient should be ignored. It also seems that many companies have studied this area in depth and more than one company knows a lot more than we know about why it is possible for these side effects to happen.

" The compounds of formula I have a good activity on the 5-HT.sub.5A receptor. Therefore, the invention further provides methods for the treatment of depression (which term includes bipolar depression, unipolar depression, single or recurrent major depressive episodes with or without psychotic features, catatonic features, melancholic features, atypical features or postpartum onset, seasonal affective disorders and dysthymia, depressive disorders resulting from a general medical condition including, but not limited to, myocardial infarction, diabetes, miscarriage or abortion), anxiety disorders, (which includes generalized anxiety and social anxiety disorder, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, psychotic disorders (which includes schizophrenia, schizoaffective disorders, bipolar disease, mania, psychotic depression, and other psychoses involving paranoia and delusions), pain (particularly neuropathic pain), memory disorders (including dementia, amnesic disorders and age-associated memory impairment), disorders of eating behaviors (including nervosa and bulimia nervosa), sexual dysfunction, sleep disorders (including disturbances of circadian rhythm, dyssomnia, insomnia, sleep apnea and narcolepsy), withdrawal from abuse of drugs (such as of cocaine, ethanol, nicotine, benzodiazepines, alcohol, caffeine, phencyclidine and phencyclidine-like compounds, opiates such as cannabis, heroin, morphine, sedative hypnotic, amphetamine or amphetamine-related drugs), motor disorders such as Parkinson's disease, dementia in Parkinson's disease, neuroleptic-induced Parkinsonism and tardive dyskinesias, as well as other psychiatric disorders and gastrointestinal disorders such as irritable bowel syndrome (WO 2004/096771). "

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Hi Denise, Mamawannawin, Karla & everyone,
Today I "celebrate" two months off of Yasmin. I am still plagued with panic and anxiety, but to a lesser degree. I am now taking Effexor XR 37.5 (EFFEXOR XR is a once-daily SNRI (serotonin-norepinephrine reuptake inhibitor) approved for the treatment of depression & generalized anxiety disorder (GAD), to keep the anxiety under control. Unfortunately it is an anti-depressant but it is supposed to also be for anxiety (I DO NOT have depression). I was on Paxil CR for 2 months but discontinued it due to side effects.
I also have hypertension which the doctor said is secondary to my anxiety and I am not taking BP medication. I took off 12 pounds so far, which helps. My face was so bloated when I was on Yasmin that it looked like I was on steroids.
I NEVER EVER had anxiety until I was on Yasmin. This pill has wreaked havoc on my whole system!!!! Never again.

I wish you all the best for renewed good health!

I was put on Zoloft for treatment of depression and anxiety due to an immense of stress in my personal life. At the beginning I was experiencing headaches, jaw tension, diarrhea and weird dreams. This was 2 months ago. Now I still have intense, vivid dreams, but there not bad dreams, so I don't mind that at all!! I have had NO loss of my sex drive, which a friend said I would, give it time. Thankfully, they were wrong!! I plan on being on Zoloft for 6 months, sbut so far I've seen a big change in both my attitude and emotions. BUT I also am following up with therapy, which is helping a lot too. I don't feel bad or helpless anymore about being on Zoloft or that i have had some personal issues that I needed help with. Now that I'm starting to see I wasn't the bad person in my problems, I realize that the Zoloft helped "clear my head" and helped me to start to become me again.