Psychotic features symptoms and conditions

The example that I am posting below is not the only patent for an aminoquinoline derivative that is proposed for the treatment of neuro-psychiatric disorders. Even though we are not comparing exact chemical structures, it is certainly worth considering how the quinolines relate to this receptor.

It is also worth considering why montelukast, a quinoline, seems to be causing some of the problems that this owners of this particular patent think that they can treat.

As I mentioned before, I have no answers. Regardless of how small Merck believes the population of Singulair patients who suffer neuro-psychiatric disorders is, I do not believe that any patient should be ignored. It also seems that many companies have studied this area in depth and more than one company knows a lot more than we know about why it is possible for these side effects to happen.

" The compounds of formula I have a good activity on the 5-HT.sub.5A receptor. Therefore, the invention further provides methods for the treatment of depression (which term includes bipolar depression, unipolar depression, single or recurrent major depressive episodes with or without psychotic features, catatonic features, melancholic features, atypical features or postpartum onset, seasonal affective disorders and dysthymia, depressive disorders resulting from a general medical condition including, but not limited to, myocardial infarction, diabetes, miscarriage or abortion), anxiety disorders, (which includes generalized anxiety and social anxiety disorder, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, psychotic disorders (which includes schizophrenia, schizoaffective disorders, bipolar disease, mania, psychotic depression, and other psychoses involving paranoia and delusions), pain (particularly neuropathic pain), memory disorders (including dementia, amnesic disorders and age-associated memory impairment), disorders of eating behaviors (including nervosa and bulimia nervosa), sexual dysfunction, sleep disorders (including disturbances of circadian rhythm, dyssomnia, insomnia, sleep apnea and narcolepsy), withdrawal from abuse of drugs (such as of cocaine, ethanol, nicotine, benzodiazepines, alcohol, caffeine, phencyclidine and phencyclidine-like compounds, opiates such as cannabis, heroin, morphine, sedative hypnotic, amphetamine or amphetamine-related drugs), motor disorders such as Parkinson's disease, dementia in Parkinson's disease, neuroleptic-induced Parkinsonism and tardive dyskinesias, as well as other psychiatric disorders and gastrointestinal disorders such as irritable bowel syndrome (WO 2004/096771). "

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I have been taking Geodon for 3 yrs and have been trying to get off of it. I started on 40mgs once a day and was driving crazy from the Withdrawal side effects my pdoc and I did not anticipate. Geodon should be taken twice a day to even out the effects. Geodon has a wear off effect. About two yrs ago I was upped to 100 mgs a day and dealt with many side effects. I take 40mgs in the am and 60mgs in the pm. Now I deal with constipation, facial twitches, something stuck in my throat constantly, feeling cold all the time. I would complain to my pdoc but we never made the connection it was Geodon doing this to me. I am considered bp1 w/psychotic features and have not had a major episode since my dose was raised to 100mgs a day. Off and on I try to wean myself off Geodon but I find it impossible. My body screams for the Geodon when I don't take it. Nausea, hot & cold flashes, a feeling of total unwellness, dizziness, loose stools & stomach cramps all start about three days after I start the weaning process and last till I take some more Geodon to make it subside. I only have Ativan to help me get off this stuff and it is not much help. I am also on 75mgs a day of Topamax. Since I was raised to 100mgs I have had real troubles with insomnia. I go to bed at 9pm and I am fully awake between 3 to 5am. I never got up that early before Geodon. Ambien does not help to keep me sleeping. I will admit my mania is gone on Geodon but I still have some low lying depression that never seems to go away. I hate Geodon because it is next to impossible to get off this medication. I have tried to wean myself down several times without success. I don't want to be attached to this drug for the rest of my life. The addiction factor of this medication is not talked about in the brochure for this medication. The Withdrawal effects are horrible if you want to taper down or get off of it all together.

My daughter started taking Singulair at age 10 - four years ago. She also started taking Carbatrol for supposed petit mal seizures (I say supposed because her last EEG read inconclusive) at the same time. Over the last four years she slowly became a different person - introverted, anxious, clinically depressed with paranoid/psychotic features and suicidal thoughts. After four years on these meds, and after a two-week stay in the hospital, I started researching the meds she was on. Discovered that Carbatrol blocks the body's natural ability to absorb vitamins and nutrients. That was a revelation to me. Then, on a whim just today, I decided to investigate Singulair's side effects and found this message board/website. (I never researched Singulair before now because for some reason I assumed it was a pretty benign drug - yikes.) All these posts confirm to me and my husband that most likely we have not only Carbatrol but Singulair as well to thank for our daughter's emotional decline and delicate mental state. I can't stress enough how vital it is to read about side effects (and NOT just the drug's official website, which is NOT going to have a complete list of possible side effects) BEFORE starting your child (or yourself) on any medication.

She has recently been weaned off her meds (Carbatrol, Effexor, Risperdal, Cogentin), and has just today begun taking the supplement Empowerplus through the Truehope.com website. I have every reason to believe this is going to be the answer - I know that these heavy-duty drugs certainly have NOT done her any favors.