Post traumatic stress symptoms and conditions

The example that I am posting below is not the only patent for an aminoquinoline derivative that is proposed for the treatment of neuro-psychiatric disorders. Even though we are not comparing exact chemical structures, it is certainly worth considering how the quinolines relate to this receptor.

It is also worth considering why montelukast, a quinoline, seems to be causing some of the problems that this owners of this particular patent think that they can treat.

As I mentioned before, I have no answers. Regardless of how small Merck believes the population of Singulair patients who suffer neuro-psychiatric disorders is, I do not believe that any patient should be ignored. It also seems that many companies have studied this area in depth and more than one company knows a lot more than we know about why it is possible for these side effects to happen.

" The compounds of formula I have a good activity on the 5-HT.sub.5A receptor. Therefore, the invention further provides methods for the treatment of depression (which term includes bipolar depression, unipolar depression, single or recurrent major depressive episodes with or without psychotic features, catatonic features, melancholic features, atypical features or postpartum onset, seasonal affective disorders and dysthymia, depressive disorders resulting from a general medical condition including, but not limited to, myocardial infarction, diabetes, miscarriage or abortion), anxiety disorders, (which includes generalized anxiety and social anxiety disorder, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, psychotic disorders (which includes schizophrenia, schizoaffective disorders, bipolar disease, mania, psychotic depression, and other psychoses involving paranoia and delusions), pain (particularly neuropathic pain), memory disorders (including dementia, amnesic disorders and age-associated memory impairment), disorders of eating behaviors (including nervosa and bulimia nervosa), sexual dysfunction, sleep disorders (including disturbances of circadian rhythm, dyssomnia, insomnia, sleep apnea and narcolepsy), withdrawal from abuse of drugs (such as of cocaine, ethanol, nicotine, benzodiazepines, alcohol, caffeine, phencyclidine and phencyclidine-like compounds, opiates such as cannabis, heroin, morphine, sedative hypnotic, amphetamine or amphetamine-related drugs), motor disorders such as Parkinson's disease, dementia in Parkinson's disease, neuroleptic-induced Parkinsonism and tardive dyskinesias, as well as other psychiatric disorders and gastrointestinal disorders such as irritable bowel syndrome (WO 2004/096771). "

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We lost our home to a house fire this past August so when my 8 year old daughter experienced severe depression, night terrors, and was constantly acting out we naturally blamed it on the house fire. The odd thing was that she had the "normal" depression immediately after the fire and started to become herself again. Several months past when she started this severe depression and horrible behavior. We brought her to a psychiatrist because this was just not the depression she was experiencing after the fire.The psychiatrist diagnosed her with post traumatic stress disorder and explained that with children it can take months for this to "come out". Well, with allergy season on us in the South, my daughter started her Singulair treatment the exact time of this recent behavior. Needless to say, we are taking her off the Singulair, I will post again to let you know if she makes a turnaround.
---by rlhulsen

This website probably saved my 9-year-old's life. He started taking Singulair in August following three major asthma attacks (his first). When he started having anxiety problems we believed it post traumatic stress as he knew he could have died in August. However the anxiety got much worse.

By November he wouldn't leave me (he had previously been extremely happy and confident). He cried continually and didn't know why. By December he was deeply depressed, wouldn't sleep or go upstairs, was frightened continually but didn't know why. By mid-Jan he had simply had enough and wanted to die. He talked of death continuously.

At that point I found this website and took him off Singualir. Within 2 days, my son who hadn't smiled for 2 months, was running around with the dog smiling, saying how beautiful a sunny day was, and could think without crying. On night five he had terrible withdrawal symptoms, walls and furniture appeared to move, and he screamed to be taken to the hospital as he couldn't control his mind. We sat it out. The next day he was better.

That was five weeks ago. All the fear has gone, all the deep sadness. He went back to sleeping in his own bed on night 7 and hasn't looked back. Yesterday he went back to school having been off for 2 months - only five weeks ago he told me he would die if I left him at school, now he's happy to be back.

This drug is very, very dangerous. I honestly believe if my son had been older he would have committed suicide. I warn every parent out there to watch their children on this drug, it can affect the mind terribly.

The thought of giving Singulair to young children who cannot explain how they feel horrifies me.

I have been on Topamax since January 2005. Currently on 200mg per day, being moved up to 400 soon. I do experience the numbness of face, which in the beginning I would take an odd childish delight in, pushing and pulling on my face (tending to be somewhat high at those times) and telling people "feel this, it's so cool" because it feels to me at those times like my face is made of silly putty. The high part is mostly gone now, and I behave like a rational adult (mostly). I still have more fun that I used to, but that is a good thing. I was one of those people who took life way to seriously before.

I was prescribed Topamax for several reasons, none of them typical. I suffer severe Post Traumatic Stress Disorder, and have been taking Celexa and Wellbutrin to treat it. Over the course of two months I gained 20 pounds on these meds. In addition, I suffer chronic fatigue and fairly severe mood swings (though nothing like what I had had prior to the medication). In light of all of those circumstances, and Topmax's reputation for causing weight loss, raising energy levels, and behaving as a mood stabilizer, I was prescribed this medication essentially for its side effects. I found out afterwards that it is benificial for chronic pain and migraines. I have had only one migraine since I began taking Topamax, and my lower back and neck problems (due do a broken coccyx and whiplash from two separate accidents) are vastly improved as well.

My craving for sweets is significantly decreased, as is my appetite, though both return with a vengeance when I get royally outraged, as I learned two weeks ago. I, also, no longer care for cola, but I don't understand why everyone complains about that, considering how it leaches the calcium out of our bones and puts us all at such great risk for Osteoporosis. I have lost 11 pounds to date. I'm sure it would be more if I would work out more or eat more than 1000 Calories per day, because I know eating so little slows my metabolism. I do suffer from dry mouth. I haven't noticed and of the blurred vision or memory loss, but despite the fact that I am very intelligent, I have always been a very myopic ditz so I wouldn't anyhow. My blood pressure, which was always low before, causing head rushes and dizziness, has stabilized at 120/60, so for the first time in my life it's normal and I no longer have to worry about falling over or having my vision black out if I stand up too suddenly. For me, I love the things this drug has done, and I am sorry to see that it is not a miracle drug for everyone else too.

Following an op on 12th Sept I was given a self administered morphine pump, (Safe measured doses??). Within 6 hours I was experiencing extremly dry mouth, and De-jevous (I knew what was going to be said or done before it happened.)Then the most terrifying hallucinations. My senses were wide open. I could hear every conversation in the ward and outside all at once and it was all going on in MY head. The smell of flowers at the other end of the ward was overpowing.
Along with this came hot and cold sweats even though my temp and pulse were normal. I had the shakes and was VERY confused and frightened and became paranoid. I ripped out all my tubes and phoned the police to say they were trying to kill me. The hallucinations lasted about 4/5 days and the rest about 3 weeks. All this was made worse by the fact that neither Docs or nurses accepted all I was going through. I had no sympathy understanding, counselling and was expected for the most part to look after myself.
I now have post traumatic stress due to how I was treated in hospital during this personal crisis.

went to the dentist a few weeks back. didn't know that they use epi with novocaine to numb teeth. started to shake real bad. took 20 minutes to get back to normal. dentist reprimanded me for being "nervous." wasn't nervous.

then in during a later appointment, another dentist was doing a deep dental scaling and planing. she had given me a similar solution as injection. I started to react the same, shaking and anxiety. she mentioned I may have allergy or hypersensititvity.

I had been diagnosed with post traumatic stress coupled with anxiety and panic attacks a few years ago. had taken medication for it for a while. symptoms disapeared until this last visit to dentist with epi/novocaine mishap. had two full blown panic attacks today. think there is a possible link since I am not in stressful or panic inducing situation in my life.

anyone else experience this?

I have been seeing a psychologist/counselor for anxiety and depression. I have a lot of anger that seems to burst out at times uncontrollably (verbally not physcially). The counsellor reccomended Paxil or Lexapro (for anxiety/depression/some Post Traumatic Stress Disorder symptoms) and had me see a psychiatrist for the prescription. The psychiatrist did not prescribe any of the SSRIs and prescribed Neurontin instead to "even out my moods." I was not very comfortable with him and thought that he may have jumped to some conclusions without truly listening to me. I am on a total of 600 mg (200 mg 3x/day) though I am working up to that level over the next few days. (Right now I'm just taking 300 mg) I've been researching Neurontin on the web and this is the first site I've really found that talks about Neurontin being prescribed for things other than fibromyalgia and pain management. (I do get migraines and he thought the neurontin may help.) I have yet to experience noticable side effects though my back and knees are beginning to hurt. Does this sound like a possible side effect of neuntin? It appears that others have been prescribed Neurontin for the same symptoms (anxiety/anger management) that I've had. I'd appreciate any feedback or contact regarding it. I'm 29, married w/ two children and am homestly quite scared about starting any medication like this. My email is ****** Thanks.