Muscle function symptoms and conditions

Iv been on 40mg for a year now i could be feeling perfectly fine then suddenly an intense tiredness comes over me and i feel very sick and start heaving quite violently and desperately need to lie down until it passes, sometimes i fall asleep and sometimes not. This is a day occurrence, sometimes even 2 to 3 times a day. This only started when i started taking these tablets. The doctor says is not anything to do with the medication but im convinced it is. Has anyone else got these side effects?

I was given 40mg Lipitor for elevated cholesterol. I took it until I started having muscle weakness .I am a retired nurse of twenty five years, and knew this symptom was not correct. So I stopped taking the medication and told my doctor of this.He did not protest in any way.My symptoms now include;two torn ligaments, sob,mental deficits, muscle wasting, night sweats, weakness,h/a's, and more. I have not taken Lipitor for two years now. Damage is done.My doctor said it should be out of my system by now. Is this a cover up?

I have been on zocor for over a year, about 8 months ago I began to have pain in my left arm, got and injection and it was better it started again in my left arm , this time there was pain , tingling, numbness, swelling , it got better but it moved to the right arm which is twice as bad, I am often brought to tears from the pain..I sometime describe the pain like shutting your hand in a car door. My Dr keep giving me the same meds.

I have been on lipitor about 4 yrs. I am a runner and keep tract of my times. I have been losing about 4% of my speed each year and have recently had a large amount of muscle fatigue. Today a ran a 940 pace and thought I was not going to make it home. Three years ago my average pace was 805. Could the 20mg dosage be causing this problem?

I am a 46 y/o male whom took lipitor 20mg for about 10 days. It was the first medication taken for me aside from occasional antibiotics. Within a week I began to develop severe nausea, weakness, postural dizziness and worst of all, chest pain at rest! I took my last dose last Saturday 8/9/08. Because of the chest pain, I went to the ER on 8/10/08 and discharged the next day after I ruled out for an MI and a negative exercise stress test. My chest pain recurred on 8/12. This AM awoke with nausea, dizziness and chest pain again. I'm going to have an adenosine stress test this PM. I consulted a pharmacologist yesterday about the metabolism of Lipitor and she told me indeed these side effects are not uncommon and in my case, Lipitor will not be eliminated from my body until probably this Sunday or early next week. Anyone experience what I'm feeling?

I have been taking simvastatin since June 28, 2008. I am 44 years old and have always been majorly active with my 17 year old daughter. Recently I have become chronically fatigued so much as to want to go back to bed within 2-3 hours after I get up in the morning, (definitely not me). I have felt spaced out,depressed to the point of wanting to cry all the time, have severe back, hip, knee, leg, and hand pain. I go to pain management for my back and hip problems (past surgery), but the usual pain has been intensified over the last 2 months and I wasn't sure why, until i decided to check out the Simvastatin to see if it has made me put on a few pounds, and boy have my eyes been opened!!!!!!!!! I AM STOPPING THE MEDICATION IMMEDIATELY!!!!!!!!!!!! Thanks to all who have spoken up, I wish I would of checked on this sooner!!!!! I'm calling my Dr. first thing in the morning!!!!!!!!!!!

By exhausted in Canton

I felt it important to share the following information with everyone adversely affected by statins, and hope it permits all to live life more abundantly. Please see the complete article in LifeExtension Magazine: *******/mag2008/feb2008_Alleviating-Congestive-Heart-Failure-With-Coenzyme-Q10_01.htm, as well as, Citizen Petition: Needed - A Change In The Labeling Of All Statin Drugs by Dr. Peter H. Langsjoen, MD, FACC a "Blue Ribbon" Board Certified Cardiologist from Tyler, Texas, who describes in detail the trouble with statins: “All statin drugs block the biosynthesis of both cholesterol and CoQ10, which explains statins’ common side effects of fatigue, muscle pain and muscle weakness, and a worsening of heart failure. When CoQ10 levels are lowered by statin drug therapy, one of the first changes to occur is a weakening of heart muscle function… In 2004, a study published in the American Journal of Cardiology showed that diastolic dysfunction (heart muscle weakness) occurred in 70% of previously normal patients treated with 20 mg a day of Lipitor® for six months. This heart muscle dysfunction was reversible with supplemental CoQ10. Heart failure that develops after years of statin drug therapy can be termed statin cardiomyopathy and may well be playing a role in the epidemic of congestive heart failure in the United States. In an effort to determine the prevalence of adverse effects from using statins, we studied 50 consecutive new patients, all of whom were taking a statin drug at the time of their initial visit. All 50 patients were found to have one or more side effects from statin therapy, so we discontinued their statin drugs and began supplemental CoQ10. Patients were followed for an average of 28 months with the following observations in the prevalence of adverse effects:
• A high prevalence of skeletal muscle pain and weakness at 64% on initial visit was reduced to 6% in follow-up.
• Fatigue decreased from 84% to 16%.
• Shortness of breath went from 58% down to 12%.
• Memory loss was reduced from 8% to 4%.
• Peripheral neuropathy decreased from 10% to 2%.
There were no adverse effects from stopping statin drug therapy with no cases of heart attack or stroke during follow-up. Overall, there was an improvement in heart muscle function on discontinuation of statin therapy and addition of supplemental CoQ10. However, due to powerful propaganda surrounding both cholesterol and statin drug therapy, many patients and physicians are afraid to stop statin therapy…Over the past five years, statins have become more potent, are being prescribed in higher doses, and are being used with reckless abandon in the elderly and in patients with "normal" cholesterol levels. We are in the midst of a CHF (Congestive Heart Failure) epidemic in the US with a dramatic increase over the past decade. Are we causing this epidemic through our zealous use of statins? In large part I think the answer is yes. We are now in a position to witness the unfolding of the greatest medical tragedy of all time - never before in history has the medical establishment knowingly (Merck & Co., Inc. has two 1990 patents combining CoQ10 with statins to prevent CoQ10 depletion and attendant side effects) created a life threatening nutrient deficiency in millions of otherwise healthy people, only to then sit back with arrogance and horrific irresponsibility and watch to see what happens - as I see two to three new statin cardiomyopathies per week in my practice.” Additionally, I have found the following newsletters/medical information helpful:
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I am a 35 yr old male and have been taking lipitor about 7 yrs. I have a genetically high cholesterol and it has been up to 275. On lipitor its around 175. Over the years I have been on this drug I went from being a normal weight and active to pretty much lethargic and sedentary due to lack of energy and gained ~50 lbs. I couldn't sleep. I got random nausea and fogginess in my brain to the point I could not remember how to perform my job. I usually had minor aches and was bloated. the past year everything has gotten much worse. For a year now, I have been getting large rashes on my body that itch severely and no medications have worked to alleviate them. I found out recently from my doctor that I have a genetic marker in my cholesterol that makes me 3 times as likely to have a heart attack. Its a portion of the cholesterol, i think its called LDL-b or something like that. Anyways, My doctor prescribed zetia to help with my cholesterol since the lipitor wasn't doing it alon. I begin feeling very sick when taking the zetia and after a week or two stopped it. The problems didn't end. As long as I remained on the lipitor, the problems seemed to continue. Its like the zetia released a dam of problems. I stopped the lipitor 4 days ago and have noticed that I feel energy coming back to me and the rash is starting to go away, but I ache severely all over. My shoulders, forearms, and legs are so sore and painful that I can't do anything about this except sleep so I don't feel the pain. I am also very weak feeling and I notice stiffness in my fingers and my grip is very weak compared to how it normally is. I have nausea and stomach cramps and constipation. I feel miserable. I notice its worse in the morning and gets a little better towards the afternoon. I typically took my lipitor in the morning. I do not know if there is a relationship here. Please advise on any help you can provide.

KMJ
07-30-08

Have been taking Zocor for a month. I am about to give it up starting tomorrow. Calling my doctor. I rather try flax seed in my diet. Have had normal cholesterol for life, however the last couple of years it has been hovering around 230-260 esp. since menopause. So, the last check up the doc put me on 20mg, I don't like how I am feeling. Very tired. Low level of energy, and my skin tone appears to be changing yellowish color. Has anyone else experience the dis-coloring of their skin? I am nervous.

I would encourage every patient on statins to read the recent article (Feb. 2008) by Dr. Peter Langsjoen, MD/Cardiologist: http://www.lef.org/magazine/mag2008/feb2008_Alleviating-Congestive-Heart-Failure-With-Coenzyme-Q10_01.htm

The following information from this article is pertinent to complaints of muscle pain/weakness and fatigue:

"All statin drugs block the biosynthesis of both cholesterol and CoQ10, which explains statins’ common side effects of fatigue, muscle pain and muscle weakness, and a worsening of heart failure. When CoQ10 levels are lowered by statin drug therapy, one of the first changes to occur is a weakening of heart muscle function, known as diastolic dysfunction. This has nothing to do with diastolic blood pressure, but rather represents impairment in the relaxing or filling phase of the cardiac cycle. After heart muscle contracts, it takes a great deal of cellular energy, or ATP, to re-establish the calcium gradients such that muscle fibers may relax. Thus, if diastolic dysfunction is severe, it can result in congestive heart failure. In 2004, a study published in the American Journal of Cardiology showed that diastolic dysfunction (heart muscle weakness) occurred in 70% of previously normal patients treated with 20 mg a day of Lipitor® for six months. This heart muscle dysfunction was reversible with supplemental CoQ10."

I hope this information will be of help to patients suffering adverse reactions from statins..

I am a male of 67 years old. I took Lipitor for a year, and after a few months of taking it, I felt muscle pains in my arms and shoulders, as well as my back. I felt weak and could hardly put my socks on by myself. I told my family doctor that I thought the problem was caused by LIpitor. He said it couldn't be possible, but he couldn't figure out what was wrong, so he sent me to a rheumatologist, who gave me an initial diagnosis of polymyalgia rheumatica. I went back for a checkup, and although the sed rate was normal, the C-reactive protein was elevated. He felt his diagnosis was an accurate one. He prescribed prednisone for me. I had some doubts about it, since I am diabetic, and was concerned about the elevated blood sugar it might cause. Well, it did elevate my blood sugar, and I weaned myself off it within three months. My blood sugar went back to normal, and while the prednisone helped the symptoms of muscle pain and aches, after I stopped it, the pain returned with a vengeance.

About a year passed after discontinuing the prednisone, and I felt worse and worse. Any time I engaged in physical activity, such as yard work, I was almost incapacitated for two or three days. I felt weaker and weaker, and by now, my activity is about ten per cent of what it was three or four years ago. I am unable to do anything physical without paying a heavy price.

I would tell the doctor that I felt the problem was caused by the Lipitor. He would dismiss my comments, saying that the pain should have gone away after discontinuing Lipitor. He sent me back to the rheumatologist with results of recent blood tests. Both the sed rate and C-reactive protein were normal. The rheumatologist touched my back and other areas, which caused me to jump. He said it might be fibromyalgia. I told him again that I thought it was caused by the Lipitor. He said the same thing my GP had said: if it had been the Lipitor, the pain would have gone away when I stopped taking it. I know the Lipitor caused the pain, because I tried red yeast rice for a couple months. The pain increased to almost unbearable, so I discontinued the red yeast rice. If I were not susceptible to the pain from the Lipitor, would the red yeast rice have increased the pain?

So here I am with a fuzzy diagnosis from the rheumatologist, and no clue from my family doctor (that he will verbalize, at any rate). My life has gone steadily downhill. I used to be a strong, active person, but now I can do very little, and my strength is a shadow of what it formerly was. What can I do?

I just spent 3 days in the hospital due to taking simvastatin.
I was having weakness in my legs and arms, to the point that I could not walk up steps. I finally went into emergency when I took an attack that resembled a heart attack, shortness of breath, cold sweat, trembling and
nausea. They flushed my body with saline solution for two days. I now have the use of my legs, but am very weak.

Let me begin by telling you that I am a nurse with 28 years experience. My father is 76 years old with a history of cardiac problems. He has been on Lipitor for 8 years. In the past two months he has developed muscle pain that had gotten to the point he could hardly walk. His doctor diagnosed him with "arthritis." His joints did not hurt and I questioned his diagnosis. What he has is fibromyalgia. Muscle dysfunction caused by Lipitor. We have taken him off of the drug and he is improving. In place of Lipitor he now takes 2000 milligrams of vitamin C daily. Vitamin C is a natural way to control cholesterol. In my opinion I suggest anyone taking symvistatin in any form should stop immediately. It is a very dangerous drug. If you think this is what you have please request your physician order the following two tests.....CPK and serum myogluten levels. Cholesterol is very important to muscle function and that is why it is produced by the body. Zocor, Lipitor, ( symvistatin) inhibits the production thus lowering the level. Let me add that prior to this condition onset my dad was riding his bike 3 plus miles a day and could out walk me any day of the week. This drug has disabled him. We are hoping for a full recovery but that is yet to be seen.
Thank you ******

The cholesterol theory on heart disease is now an old wives tale. We have been lowering cholesterol for about 35 years now, and heart disease marches on unabated.

If the populations had never latched onto the belief that cholesterol causes heart disease, statin drugs would have never been developed. After all, if there is no market for it, why develop it?

But we ( including myself) believed that cholesterol was an evil villain ready to strike us dead if we didn't control serum levels of this deadly substance. WE WERE WRONG!

Cholesterol is very important in maintaining proper nerve and muscle function. Cholesterol plays an important role in the production of steroid hormones including testosterone.

PS: Restless Leg Syndrome: Probably caused by magnesium and calcium depletion, as the diuretic-effect of Neurontin exacerbates electrolyte imbalance. You should fast-fast have your doctor check this, and see what supplements you should take (potassium also affects muscle function, as erll, but it's a complicated and delicate balance.) JanK