Family history symptoms and conditions

Well I too am having "weird" symptoms. It may be due to Omeprazole but not sure at this point. I switched from Prilosec OTC to Omeprazole which I thought to be the exact same thing. A couple months after the switch I am having chest tightness. Not really pain but just a weird feeling in my chest that almost feels like anxiety or stress and kind of a general weird feeling. Also kind of feels like a chest cold without the mucus that goes along with it. Went to the doc and had a EKG which was normal. I'm 30 years old and don't have any family history of heart issues.

I'm going to stop taking it for a few days to see if the symptoms get better. I'll post back in a week or so.

My eight year old son, who has asthma and has been taking Singulair since he was three, has been off Singulair for four days and is becoming a completely different little boy! He has always been a "difficult child" with intense emotional reactions to things, anxiety, oppositional behavior, a short fuse and bad temper. He has also displayed obsessive/compulsive behavior. His father and I never thought that his behaviors and symptoms were caused by Singulair. His pediatrician never suggested it. With a family history of anxiety, we just assumed it was the way he was. At four, his preschool requested he be tested for ADHD. The testing revealed a short attention span but not a diagnosis of ADHD. As he got older his symptoms grew more intense. Last year we considered taking him to a psychiatrist but decided to "wait it out" one more year to see if maturity would bring an end to some of the behaviors. It didn't and in fact they grew worse. He became aggressive, explosive and depressed.

I recently began taking Singulair for another medical condition and had noticed that it made me a little moody. Last week, on the verge of making an appointment for my son with a psychiatrist, I started to wonder if maybe he was reacting in a similar, yet more intense way to the Singulair. I reviewed the patient information on line (I had read the patient info for Singulair when my son started taking it, but had not done so in years. I learned a tough lesson: check the information that accompanies prescriptions each and every time I get a refill.) When I read what the "less common side effects" were I was convinced that my son was reacting to his medicine. Then I found this website. We stopped his Singulair immediately and within two days began seeing a dramatic change in our son. He was less high strung, defiant, and explosive. Yesterday we had a cookout with some friends and he played with other kids all day without fighting for the first time in his life! He even cooperated when we asked him to help us get ready for company.

I strongly believe that this medicine should not be given to children and teens. I am so upset that when I asked my son's pediatricians about his behavior TWICE last year, they never mentioned that Singulair could be the problem. I called today to tell them he wasn't taking it anymore and the nurse said that she would note that he is "allergic" to it in his chart!

We are exploring alternate and natural ways to treat our son's asthma. I will NEVER give him Singulair again!

FYI: the labeling for his albuterol inhaler states that "safety and efficacy have not been established in patients under 12 years old". His pediatrician has been prescribing albuterol inhalers since he was three!

Does anyone have information about herbal inhalers and naturopathic treatment of asthma? If so I would like to hear.

Well now it all makes sense! I am just finishing my 2nd week on Femcon FE and I couldn't understand why my breasts hurt so much...now I get it! I was on the depo shot for 2 years and LOVED it, no migraines, no periods...nothing. But because of my age and family history of osteoporosis I had to go off of it. Another doctor in my doctor's practice put me on the femcon because after not having my period for 2 years I got it really bad twice for a week in 3 weeks time. I can't go back on Yasmin because of the migraines, however besides the tenderness issue (which sucks if you have to run/walk fast anywhere), and I'm convinced weight gain, all of the sudden nothing fits. I'm not having the bleeding everyone else seems to be. But when I go for my annual in a week, I am going to definitely ask for something else after being on BC for the last 12 years this has to be the worst.

hi,daer777 i like to know the natural product that lower cholesterol.also since you stop the medication any changes or not if you don't mind?I took my father to many neurologist and they test many Parkinson medication and my father did not respond to any medication but he got worsed,yesterday he had another appointment to another neurologist he said if it is not Parkinson disease then must be genetic disorder witch is we never had in our family history and also doctor noticed that many my patient who are using lipitor responding very well with Parkinson medication ,and when i said about lipitor he got mad on me and very rudely said medication never doing this and don't blame medication,so every doctor that i saw never believed us that lipitor or ezetrol (zetia)is that cause.also doctor said if it is the medication then he must be symptom free by now ,he quit ezetrol just three months ago and lipitor 2 years ago.

hi, dear 777 i like to know about the natural product that lower cholesterol .and also like to know since you stop the medication any changes accure or not?i took my father to many neurologist and they test many Parkinson medication and no response yesterday i took him to another neurologist and and he diagnose him to genetic disorder witch is we never had in family history and he got mad on me when i said about the cholesterol medication side effect.what was his answer that when he quit the medication he should get better and as i said coz months ago he improved 80%,he said it is impossible and if it is it is miracle so no doctors are believing that medication is the cause.most symptom is disappeared but his walking and stiff muscle is not improving yet except some times.

I just wanted to share my experience with Mirena and hope that it helps someone else. I had Mirena inserted on 7th July 2008 after having a copper IUD removed. I chose the Mirena because I had heavy periods and understood that the hormone would be localized to my uterus and only a very small amount would enter my bloodstream.

After a very short time (probably a day or so), I started getting symptoms of nausea, headaches, dizziness, forgetfulness, depression, bloating, cramping and just a general feeling of something wrong with my body. One day I was just sitting at my desk at work and my heart starting racing! I also felt very anxious and panicky a lot of the time.

The nausea and headaches just got worse every day until I couldn't stand it any longer - I was completely miserable - and called my doctor's office to make an appointment to have the Mirena removed. When I went to the appointment, my blood pressure was sky high and I had a severe headache. Although my doctor said she believed I was having these symptoms, she didn't think the Mirena could be the cause.

Anyway, I had the Mirena removed on July 25th and a few hours later, my headache had completely gone. I slept great that night and woke up for the first time in 2 weeks not feeling nauseous. I had my blood pressure checked today (2 days later) and it was back to normal.

I'm pretty sure that the Mirena made me sick and I wish I'd done some research before I had it inserted. It's been interesting to learn that so many people are experiencing similar problems.

Our daughter spent her 21st birthday in ICU, Sunday the 13th. I took her to the ER with shortness of breath, chest pain and nausea on Saturday afternoon. She has been on Yaz since February with only the mild symptoms of: loss of apetite, mild nausea and some abdominal cramping. She was put on this BC to regulate her periods and relieve menstrual pain as well as excessive dark facial hair growth. All 3 of these were relieved by Yaz.
She has now spent 1 week in the hospital (2 days in ICU) and will be on coumadin for 3 to 6 months due to a very large pulmonary embolism (size of my knee cap) that was putting the right side of her heart in distress. She also has multiple clots in her right lung.
I am shocked to read through this website and see all that has happened to so many women. She can never take oral BC again in her life. There are no blood test results that indicate she was even predisposed to this type of reaction and is not family history.

I'm experiencing some VERY concerning symptoms and have a feeling it might be from the Mirena. And my doctors think it's just stress! SOMEBODY HELP!

I had a baby 4 months ago and at my postpardom appointment I was talked into getting the Mirena. After I had it inserted it all started with severe cramping and light bleeding that still has not subsided. I have been suffering with chronic headaches, dizziness, and facial numbness. I've also had bouts of anxiety and leg cramping and recently starting to have pain in my neck and one of my lymph nodes on my left side has become present and tender to the touch.

I mentioned all the these symptoms to my OB/GYN and he said "it's NOT related to the Mirena, go to your Primary Care Dr. and get some tests done" Well, I did that, got a full CBC and had my thyroid checked and all of my blood work came back normal. My Dr. said I am stressed after having the baby and to get some rest. I really wanted to have a CT done but after reading this I am beginning to think it's the Mirena as I had not had any of these symptoms prior to the IUD. I think i'll make an appointment to have it removed.

Anyone ot there have any of my exact same symptoms???

My daughter took Yasmin for two months and 18 days. She began to experience anxiety but the nurse told her that Yasmin "took some getting used to." My daughter decided to give it one more month. In the 3rd month she experienced shortness of breath and some "funny little bloody noses." She had no symptoms of DVT's in her legs (pain or swelling). A doctor examined her on Wednesday and diagnosed "anxiety." On Thursday her nurse reassured me that the shortness of breath could definitely be caused by anxiety. Friday morning she collapsed in her dorm room. She turned blue. She was taken to the ER. She DIED eight hours later of massive pulmonary emboli.
Don't let this happen to you or someone you love. Know ALL the symptoms of blood clots in the legs OR in the lungs. These symptoms are buried in small print in the middle of the booklet. If you develop symptoms go to an ER IMMEDIATELY and insist on being checked for blood clots. Tell them you are on Yasmin. Do not accept the diagnosis of anxiety unless blood clots are ruled out. In addition, if you have a family history of blood clots be tested for clotting disorders BEFORE you start a birth control pill. She was my only daughter and my heart is broken. BE CAUTIOUS. We were falsely lured into a sense of safety because it was a "low dose" pill.

I went on Simvastatin 40mgs last Christmas 2007 because of the family history of strokes, I was generally feeling very well .
Since being on statins I have felt awful , with lots of side effects " muscle cramps, upset stomach, really really tired, strange feelings in my chest and bad palpations "... I thought I was really ill.which made me very depressed.and even had test's done at the hospital to try and find what is wrong with me thankfully nothing appears to be seriously wrong" so why feel so dreadful i thought it had to be the statins!!"
I came off them my self four weeks ago ,since then I have been to see my doctor who has agreed for the time being I should be off simvastatin but consider taking a milder statin.
I do feel slightly better after four weeks ,but still get some of the side effects can any one suggest roughly how long it takes to feel like one's old self again.....Please!!!

I am in the family with the 86 year old man that committed suicide because of this drug. He was my father and I will never be able to see him again. This drug caused such severe side effects for him that he did not know what he was doing and killed himself leaving his wife of 59 years, 7 children and a host of grandchildren and great-grandchildren. He had everything to live for and had no effects of depression or other problems until he started taking the medicine. The drug made him sicker instead of better. My family has asked that we received a drug screening from the Medical Examiner to determine the combination of drugs that were in my dad's system at his death. He was also prescribed prednisone, which we have since found out should that the drugs should not have been given together. I would like to take this doctor to task for his incompetence in prescribing an elderly man medication that could cause this result. I am very angry at the physician and will pursue legal actions when we receive the Medical Examiners information. No family should have to suffer the loss that we have had and no experience the void that we have in our lives. My father was a healthy, 86 year old man with a family history of living past the age of 100. We figured he had another 20 years to go. I know that my taking legal action will not bring back my father but I would like to somehow make this drug side effects public knowledge so this DOES NOT happen to another family. This weekend is Father's Day and my only way to talk to my father is standing my his graveside. I should not be doing that. I should be celebrating another Father's Day with him at his home. This drug and his doctor caused his death. DO NOT TAKE THIS DRUG....consult your doctor if he even mentions it in a course of treatment. I would like to be able to present evidence to the Food and Drug Administration of the terrible effects of this drug and the combination of drugs that are given with it. My daughter even said she would like to be the one presenting our family story to Congress during hearing concerning removing this drug from the market. That is my goal....this drug should be removed. I have contacted the Food and Drug Administration and suggest that everyone else do the same. If they get enough complaints, they will have to open a dialog on the drug and some of the families will have the opportunity to speak about the effects of the drug on their lives. I will always miss my father and love him dearly. I know that he was not in his right state of mind when he committed suicide and that the drug caused his actions. My mother found him that day in April when she came home from the store. She will never be the same nor will our family. Again, DO NOT TAKE THIS DRUG!!!!!

I have stated many times that I am not an expert. I just post what I find. This has been a mind boggling journey for me. This is way over my head but I struggle to read and understand. Finding answers to why children are suffering from neuro-psychiatric side effects is worth the effort.

I have made the following observations.

1. Some quinoline are known to be able to cross the blood brain barrier.
2. Molecules that ionize are known to be more likely to be able to cross cell membranes. So if montelukast ionizes as a result of change in blood pH to sufficient acid conditions that it ionizes, then it could be possible or maybe like that it does in fact cross the blood brain barrier.
3. We know that there are cysLT1 receptors in the brain.
4. We know that researchers believe that montelukast may bind at the arginine of the cysLT1 receptor.
5. We know that arginine contains four nitrogens. And montelukast contains one.
6. We don't know what happens to those nitrogens.
7. We do know what macrophages create nitric oxide as I posted.
8. We do know that if something cause excessive nitric oxide to build in the brain that there would be damage to the neurons.

Some people may remember when I got stuck at the astrocytes, the cysLT1 receptors and glutamate. I keep looking for research reports that may shed more light on this.

Titre du document / Document title
Nitric oxide causes glutamate release from brain synaptosomes
Auteur(s) / Author(s)
MCNAUGHT K. S. P. (1) ; BROWN G. C. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Biochemistry, University of Cambridge, Cambridge, ROYAUME-UNI
Résumé / Abstract
We determined the ability of pathological levels of nitric oxide (NO) to cause glutamate release from isolated rat brain nerve terminals using a fluorometric assay. It was found that NO (0.7 and 2 μM) produced (4 and 10 nmol/mg of synaptosomal protein) Ca2+-independent glutamate release from synaptosomes (after 1 min of exposure). Spermine/NO complex (spermine NONOate; a slow NO donor) and potassium cyanide (an inhibitor of cytochrome oxidase) also caused Ca2+-independent glutamate release. Preincubation of synaptosomes with 5 μM 1H- oxadiazole quinoxalin-1-one (an inhibitor of soluble guanylyl cyclase) had no effect on NO-induced Ca2+-independent glutamate release. Ca2+-independent glutamate release produced by NO was greater in a low-oxygen medium. NO, spermine NONOate, and potassium cyanide inhibited synaptosomal respiration with a similar order of potency with respect to their ability to cause glutamate release. Because NO has been shown previously to inhibit reversibly cytochrome oxidase in competition with oxygen, our findings in this study suggest that NO (and cyanide) causes glutamate release following inhibition of mitochondrial respiration at the level of cytochrome oxidase. Thus, elevated NO production leading to mitochondrial dysfunction, glutamate release, and excitotoxicty may contribute to neuronal death in neurological diseases.
Revue / Journal Title
Journal of neurochemistry ISSN 0022-3042 CODEN JONRA9
Source / Source
1998, vol. 70, no4, pp. 1541-1546 (29 ref.)

INIST-CNRS, Cote INIST : 4037, 35400007527188.0230

I had been taking Yasmin monthly for 8 months with no problems. One week I had horrible leg cramping and pains in my calf. I thought it would go away but after going to the doctor and getting an ultrasound done on my leg, it turned out to be a DVT (deep vein thrombosis). I had to go to the emergency room and be admitted for 5 days. That is also where they told me that I had 3 blood clots (Pulmonary Embolisms) in my lung. I'm only 28, healthy, nonsmoker, P.E. teacher and was diagnosed with blood clots that are from Yasmin. I have no previous health problems and no family history of blood clots. I WOULD NOT TAKE ANY HORMONES IF YOU DON"T HAVE TO!!! Yes, for some people it may not be a possibility but at least don't take Yasmin. With blood clots you can not do anything strenuous, no relaxing massages, no visits to the chiropractor, no random medication like Ibuprofen without doctors approval, no alcoholic beverages since I was on blood thinners. I was moody and miserable when this happened since I had to immediately stop taking Yasmin and was in the hospital with blood clots. Thankfully the blood clots are gone but I'm still on blood thinners and have to be very careful for the rest of my life.

I took Yaz for about 6 weeks. After week 4 I noticed I had heart palpitations, shortness of breath, abnormal mood swings - always upset and easily frustrated by the smallest things. The change in my mood was noticed by everyone from my family and boyfriend to co-workers and business associates. I myself noticed this big change. After week 5 I had a huge breakdown where I literally felt my heart thumping out of my chest...it felt like a heart attack (I can only guess). I could not breathe. I brushed it off as nothing (big mistake). Exactly 9 days later I was at work and the exact thing happened to me. This time I could not function - could not breathe, heart palpitations, the works!. I work in the medical field and so I my blood pressure was taken by a colleague and it was 168/108 on the left hand and 159/109 on the right (can you say OMG!!!). Sure enough I was rushed to the ER and they managed to bring my BP within normal range. The doctors told me I was knocking on the door of a pulmonary embolism(PE) (bolt clot in the lung) and/or a heart attack. I am a 24 y/o athletic, very fit, never even had a cold female who is extremely healthy. I take OC for PCOS for about 2+ yrs now. I made the switch from Yasmin to Yaz 6 weeks ago as I wanted to try something new with more 'so called' benefits (fewer periods and helping with moods swings that I also attribute to Yasmin).
I have done so much research and read so many experiences of other women on OC and none have as much reported MAJOR SIDE EFFECTS that Yaz and Yasmin...especially YAZ. While I agree with posts that notes that all OC have side effects; it should be noted well that YAZ is the worst.
Ladies...DO NOT TAKE YAZ IF YOU WANT TO LIVE! This is no joke.
I am happy to report that I am back to my happy healthy self. I am staying clear of all OC and will just live with my PCOS until I am ready to have kids.
Blood clots, PE, heart attack, HTN etc. is no joke. CHOOSE LIFE. They should take this drug off the market.
If you must take an OC, try ortho try-cyclen lo or talk to your doctor in details and to the health risk of them all and the one with the least side effects.
I appreciate this site for affording us ladies the opportunity to share our experiences, learn from the experiences of others and avoid a costly mistake.
God bless.
S.D. - FL
P.S. - DO NOT TAKE YAZ

I am also experience hair thinning while on Wellbutrin. I have had blood tests and there is no other detectable cause. The dermatologist said that she was only able to diagnose as possibly hereditary. However, I began noticing it shortly after starting 300mg of Well XL and then noticed increased thinning when I went up to 450mg. I don't take any other medications at all.

I searched the Wellbutrin prescribing information (a pdf on the official Wellbutrin website) and this is all I can find:

Other Events Observed During the Clinical Development and Postmarketing Experience of Buproprion

Adverse events for which frequencies are not provided occurred in clincial trials or postmarketing experience with bupropion. Only those adverse events not previously listed for sustained-release bupropion are included. The extent to which these events may be associated with Wellbutrin XL is unknown.

Skin: Rare was maculopauplar rash. Also observed were alopecia, angioedeme, exfoliative dermatitis and hirsutism.

----------------

Alopecia is hair loss. All that means is it was reported and they didn't do a study that would have produced data with which they could measure the likelihood that it is a Wellbutrin side effect. In other words, people said they were experiencing it but they can't confirm it.

I just dropped down to 300 mg and I'm contacting my shrink about tapering off completely - I feel like dealing with scalp showing through and feeling horribly self-conscious and unattractive because of it is not going to help my depression and self-esteem issues any.

I'm a woman by the way - the number of reports of hair thinning in women seems significant to me. I have no family history of thin hair on the female side that I know of.

I am a hill walker. My name is Steve and I am 58 years old. I have been recently diagnosed as having type 2 diabetes. Fair enough. I have been given dispersible aspirin, metformin to lower blood sugars, ramipril to reduce blood pressure and SIMVASTATIN to reduce cholesterol. This drug (Simvastatin) made me so Ill that I couldn't walk up my drive without feeling as if I was going to pass out. I also suffered tummy pains, felt very sick and my heart was thumping and banging like a base drum. Every joint in my body ached so badly that I thought my walking days were over for good. I stopped taking it four days ago and already feel better. My doctor has given me a replacement medicine called PRAVASTATIN but I am frightened to take it, fearing that it may create the same or similar problems. Has anyone got any comments or experienced problems with Pravastatin? I would appreciate any feedback that you might be able to give, positive or negative.
Regards,
Steve.

Visited new physician, blood test showed recent spike in LDL level (+60 points). Test was non fasting, and not repeated. At follow-up visit, doc directed me to take Lipitor, and when I expressed concern about taking drug before trying diet and other tactics for lowering LDL, doctor brooked no discussion. I specifically expressed concern regarding dizziness, as I had had very severe neurological problems after taking a high level of an OTC at a doc direction for an unrelated problem. My concern was dismissed out of hand (I've never seen it in 20 years.) No return visit was scheduled at this time to check on efficacy. (A medical student was in the exam room, I never spoke with the doc alone, and the doc left the room and I never saw her again.

Without other immediate options for medical care, I filled the prescription for 20 mg of Lipitor. At about the second week, I began to experience severe neurological problems (dizziness, sense of no orientation of my body in space, trouble keeping upright, etc.) I received a card for a cardiology appointment shortly after the visit, and decided to hang on until the visit. The cardio doc said to me, "why are you here?" I told her that the appt. had been scheduled by the other doc's office, but told her what I knew. She took bp - told me it was fine (actually, it was prehypertensive), and then told me my high LDL was genetic, and I'd have to be on drugs for the rest of my life (56). Did not ask for family history, and ignored recent severe leg infection as a possible cause for the spike in LDL.

Having been offered no alternative, I decided to stop Lipitor on my own after 19 days on it. (I decided I would rather drop dead than feel as I did.) Not much improvement immediately. It took 30 days off it to have a day on which I felt well. I am into my second week since then, and have an occasional bad spell, but I am hopeful I'll have a full recovery from the neurological problems. I've been on my own low fat diet for the LDL, but don't know what effect that is having, and have no intention to visit a doctor to find out.

Interestingly, the FDA's Medwatch only allows reporting of severe side effects, and I didn't stay on Lipitor long enough to meet the definition (become disabled).

As MANY of you have posted, "I thought I was just getting 'old." Now I know it's the statins. I thought I was doing the right thing because I have family history of cholesterol problems. I was first on pravachol, then lipitor for a few years, now Vytorin - which dropped my numbers to the lowest ever - 190.

HOWEVER - I have never felt worse. I have all the 'symptoms' described in this blog. Reclusive, depressed, extreme shoulder/neck stiffness and pain. Low back, and hip joint pain (severe). I can't even workout because I don't have the stamina to go through my routine. LOSS OF MEMORY!! This is severe. I use to be able to memorize hundreds of numbers or addresses and now can't remember a number that I looked at 2 seconds ago! This is insane! They need to remove this drug from the market. I'm done with statins.

Unfortunately my lawyer told me that they do not want to take our case because of the lack of evidence that Singulair has caused our daughters problems. :(

Does anyone out there have a pending class action lawsuit that We may be able to get in on? I have tons of proof that Singulair has caused our daughters problems and loss of almost 5 years of her elementary school career!

My phone number is *** and my email is ****** if You email me please put "Singulair" in Your subject line so I know it pertains to this posting.

Thank You in advance,
Chuck & Brenda
Jamestown New York

Our son started taking Singulair when he was 2 for severe allergic rhinitis and cough variant asthma (in addition to Zyrtec, which didn’t control all of his symptoms). He is 5 now. For the last three years, he has been an increasingly violent, difficult, defiant, argumentative, volatile child who has intense mood swings--one minute he’s laughing uncontrollably, the next he’s weeping over nothing. His doctor and therapist recommended that we see a psychiatrist to have him evaluated for bipolar disorder, which used to be unknown in children. Because he has such chronic sleep problems, the doctor also suggested we take him off Singulair (and increase his Zyrtec dose) to see if it improved his sleep issues. Within a week, he was sleeping much better and was a calmer, happier, gentler boy. He suddenly could take “no” for an answer without flipping out and trying to hurt me. We thought that we were just in an unusual, calm window that would shift either to mania or intense sadness or both, any minute. We also thought that his behavior change might be due to sleeping better. We were enjoying the rare reprieve. Over the last weekend, his springtime allergies really flared up. We gave him Singulair on Monday and by noon, he was completely out of control. I had to strap him into his car seat at one point to keep him from hurting either me or himself. It finally occurred to me that Singulair might be causing his “bipolar” disorder. Of course, we stopped the Singulair. After two days he was a new boy. Yesterday, I Googled “Singulair bipolar children” and got a few hits. I am stunned to read how similar other families’ experiences have been to ours and I feel sick that we gave this drug to our child for three years.

I'm a 46 years old male normally good shape,I was put on Lipitor due to high cholesterol and family history of heart problems.I've been on lipitor for four years , 2years on 10mg, 1 years on 40mg and 1 year on 80 mg.
The last 6 months I have been experiencing severe archiles tendonitis to the point where I can hardly walk. I am extremely disatisfied with this drug and have read a lot of complaints regarding this drug.

Has anyone else experienced this side effect?

Please reply to this post.

Thank You

I noticed a lot of postings about weight gain on Singulair, which is nowhere listed by Merck as a possible side effect. My 15 y.o. daughter experienced sudden weight gain at the age of 9 when she was actually underweight (BMI went from 17 to 21). To make a long story short, after being off Singulair for over a year, she is now over-weight, and diet/exercise have never made a big difference (gymnastics, swim team, figure skating, trampoline, etc.) Extensive labwork is always normal & there is no family history of obesity. It's a shame the quality of life of a child is RUINED by a drug that is deemed to have "no side effects", and the many drs. & specialists out there take it very lightly. We continually worry about our daughter's self-esteem, risk of diabetes, and other complications from weight gain which is not hereditary and goes on unexplained by the drug co. Reversing this weight gain has been nearly impossible. Everytime I hear a news report about our children being overweight and obese, it makes me angry because I think about the many kids that are taking this highly prescribed drug (for even the mildest allergy or asthma) and who knows how many parents don't make the connection!

I think that I can get my head around certain things and try to explain to you that medications do not work for all people or affect all people the same way. Well, that sounds simple enough to say - DUH. But, it is actually quite complicated chemically. Human beings are not chemically the same because we have variations in our genes. Would you be surprised to learn that about 60% of adverse drug reactions involve certain chemicals (in some cases enzymes) that we already know what these chemicals or enzymes are and what the variants are among populations groups? Some times we can predict who would have an adverse reaction to what medications if we knew what gene subgroup the patient was part of. We could also predict whether the patient would metabolize a drug at the same speed as others or not. Metabolize means utilize the drug and then discard the by-products--mostly the liver is the recycling center of chemical waste. Anything that the liver cannot re-use, the kidneys gets rid of in the urine. Speed of metabolism is a very important thing because people who are slow metabolizers might actually experience over-dose. There are other differences caused by genes that can cause different reactions according to the individual person.

I am interesting in following this site because I am wondering if the concept is flawed meaning that other parts of the body were ignored at the expense of controlling asthma and allergies of the nasal passages and lungs. OR - is there just a problem that relates to genetic differences in something such as enzymes and certain populations groups do just fine on Singulair with no problems and other people have some awful problems?

This isn't my area. But, sadly, if I can spend two weeks looking at this and come up with at least a road map of what I am looking for to answer some important questions then people who do this for Merck already know the answers. Why do I say that? Because, the adverse side effects (major categories) correspond to important areas of leukotriene receptor location and activity. Maybe not necessarily this receptor but part of a chemical process that involves this receptor.

The bottom line is that Singulair is the wrong medication for anyone that has adverse reactions. OR, there is a problem regarding the dosage that involves how fast the patient metabolizes the medication. Considering that there is a link to psychiatric adverse drugs reactions in Singulair and some medications for depression are linked to differences in metabolism due to enzymes, then there could be possibly something important to be learned from Singulair adverse drug reactions.

The biggest problem is that pharmaceutical companies are not properly communicating with the doctors who prescribe their medications. Why not communicate to doctors to look out for side effects and be aware that there are gene variations among people that are directly linked to how the patient might respond to the medication?

What happens if the patient belongs to the gene group that will have problems? If the pharm company does not tell the doctor to be on the alert, then the doctor tells the patient that it is not the drug that is causing the problem. Then the gene groups with the problems, go on the war path.

Hi All! So glad to read of all the "happiness" since off of singulair. My 2 sons and I are off for a week now and what a difference. My 6 year old is back to his old self. He is much happier and is laughing a lot and not throwing angry tantrums. My 8 year old feels much better as well. He is much calmer and has had only one outburst in a week compared to daily. I can't wait to see if he can come off of ADHD meds too. I feel much more laid back. I thought my mood swings were hormonal but since I have had a hysterectomy, I thought they should subside. My estrogen level seems good but I just thought I was being female! I can tell a difference now and I feel better. I am getting along with just my asmanex for now. I wonder if the singulair really even helped me at all. I had a little tightness the first few days but now I feel just like I did on the singulair. To me this med is just not worth the risk. We have no family history of ADHD or depression so I wondered why my boys had the thoughts and symptoms they did. Singulair was the only drug my youngest was on so I know his symptoms came from that. Good luck to everyone and thanks for the posts!

I have been on Yasmin for almost 2 years. First 1 1/2 seemed great. I am taking it because my ovulation 8 to 10 days is very painful and bloated and constipated and then my PMS another 10 to 14 days severe cramps, severe all pms symptoms. Last few months have been exercising and cutting calories and have lost not one pound, always had headaches but could be worse, but weirdest thing is At the GI doc today my blood pressure was high. I have never had high blood pressure. I am going to be 45 and I am not over over weight, maybe e can lose 10 to 15 pounds. No HB pressure in family history. Very concerned I think I am just going to stop it. Anyone else with onset of High Blood Pressure, please e-mail ******