Hydrochlorothiazide-Lisinopril Information

What's inside Hydrochlorothiazide-Lisinopril

Recent Hydrochlorothiazide-Lisinopril Side Effects

Posted by r50880 8 days ago
I've been on Lisinopril-HCTZ for about 9 months now. I stumbled across this website because I was wondering if perhaps incre...

Posted by riversns 18 days ago
I have been taking Hydrocholorthizide and 5 years and Lisinopril 20mg about 2 years. This year I beginning to notice that I ...

Posted by mll 29 days ago
this is a wonderful website. I was just put on the lisinopril hctz yesterday. My doctor said to try this first rather than ...

Hydrochlorothiazide-Lisinopril Chemical Information

hydrochlorothiazide - The hydrogenated derivative of chlorothiazide, a thiazide diuretic with antihypertensive and anti-urolithic effects. This agent binds to the electroneutral Na-K-Cl cotransporter (NKCC) and thereby impairs Na+, K+ and Cl- reabsorption on the luminal membrane of the early segment in the distal convoluted tubule in the kidney. This leads to an increase in urinary excretion of sodium, chloride, potassium, bicarbonate and water subsequently reducing plasma and extracellular fluid volume leading to a reduction in blood pressure. Hydrochlorothiazide also decreases urinary calcium and uric acid excretion by direct action on the distal tubule.

lisinopril - A synthetic peptide derivate and long-acting angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Lisinopril specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II. This leads to a diminished vasopressor activity. In addition, angiotensin II-stimulated aldosterone secretion by adrenal cortex is decreased which results in a decrease of sodium and water retention and an increase of serum potassium.